NASA Spaceline Current Awareness List #1,064 1 September 2023 (Space Life Science Research Results)

NASA Spaceline Current Awareness List #1,064 1 September 2023 (Space Life Science Research Results)

SPACELINE Present Consciousness Lists are distributed through listserv and can be found on the NASA Activity E book web site at https://taskbook.nasaprs.com/Publication/spaceline.cfm. Please ship any correspondence to Shawna Byrd, SPACELINE Present Consciousness Senior Editor, [email protected].

Name for articles to quote within the weekly lists: Authors at NASA Facilities and NASA PIs—do you might have an article that has lately printed or will publish within the upcoming weeks inside a peer-reviewed journal and is within the scope of area life sciences? If that’s the case, ship it our method! Ship your article to the e-mail tackle talked about above. Articles obtained by Wednesday will seem inside that week’s record—articles obtained after Wednesday will seem the next week.

Papers deriving from NASA help:

1

Land ES, Canaday E, Meyers A, Wyatt S, Perera IY.

Bridging the hole: Parallel profiling of ribosome related and whole RNA species can establish transcriptional regulatory mechanisms of crops in spaceflight.

J Plant Work together. 2023 Aug 28. On-line forward of print.

https://doi.org/10.1080/17429145.2023.2248173

PI: S. Wyatt

Notice: From the summary: “As crops are a vital part of sustainable life help techniques, long-duration area missions would require a complicated understanding of plant diversifications to spaceflight and microgravity. For a few years, transcriptional profiling of regular state mRNA abundances has been used as measure of plant diversifications to the area surroundings. Nevertheless, measured adjustments in transcript abundances are sometimes not mirrored in corresponding adjustments within the proteome due regulatory processes governing translation. Translating ribosome affinity purification (TRAP) is a way that selectively targets ribosome sure mRNAs for isolation and downstream sequencing. Evaluating profiles of ribosome-associated mRNAs with whole mRNAs supplies perception into the translatome and should extra precisely inform on the mobile responses to the spaceflight surroundings. Towards that aim, this work describes a strategy developed forward of the APEx-07 flight mission.” This text could also be obtained on-line with out cost.

Journal Affect Issue: 3.2

Funding: “Funding was partially supplied by NASA Organic and Bodily Sciences [grant #80NSSC19K1481] to S.E.W and I.P.”

2

Ong J, Waisberg E, Masalkhi M, Kamran SA, Lowry Ok, Sarker P, Zaman N, Paladugu P, Tavakkoli A, Lee AG.

Synthetic intelligence frameworks to detect and examine the pathophysiology of spaceflight related neuro-ocular syndrome (SANS).

Mind Sci. 2023 Jul 30;13(8):1148. Overview.

https://pubmed.ncbi.nlm.nih.gov/37626504

PI: A. Tavakkoli

Notice: This text is a part of Particular Challenge “Latest Advances in Neuro-Opthalmology” (https://www.mdpi.com/journal/brainsci/special_issues/U149EB2R55). Further articles will probably be forthcoming and could also be discovered within the hyperlink to the Particular Challenge. This text could also be obtained on-line with out cost.

Journal Affect Issue: 3.3

Funding: “NASA Grant [80NSSC20K183]: A Non-intrusive Ocular Monitoring Framework to Mannequin Ocular Construction and Useful Adjustments as a consequence of Lengthy-term Spaceflight.”

3

Gaza R, Johnson AS, Hayes B, Campbell-Ricketts T, Rakkola J, Abdelmelek M, Zeitlin C, George S, Stoffle N, Castro A, Amberboy C, Semones E.

The significance of time-resolved private dosimetry in area: The ISS crew energetic dosimeter.

Life Sci House Res. 2023 Aug 25. On-line forward of print.

https://doi.org/10.1016/j.lssr.2023.08.004

Notice: From the summary: “Monitoring area radiation is of important significance for threat discount methods in human area exploration. Radiation safety packages on Earth and in area depend on private and space radiation monitoring devices. Crew worn radiation detectors are essential for profitable crew radiation safety packages since they measure what every crewmember experiences in several shielding configurations throughout the area liveable quantity. The House Radiation Evaluation Group at NASA Johnson House Heart investigated a number of compact, low energy, real-time devices for private dosimetry. Following these feasibility research, the Crew Energetic Dosimeter (CAD) has been chosen as a substitute for the legacy crew passive radiation detectors.”

Journal Affect Issue: 2.5

Funding: “This work was carried out beneath NASA contract NNJ15HK11B.”

4

Kwiatkowski E, Suman S, Kallakury BVS, Datta Ok, Fornace AJ Jr, Kumar S.

Expression of stem cell markers in high-LET area radiation-induced intestinal tumors in Apc1638N/+ 

mouse gut.

Cancers. 2023 Aug 24;15(17):4240.

https://doi.org/10.3390/cancers15174240

PI: A.J. Fornace Jr/NSCOR

Notice: This text could also be obtained on-line with out cost.

Journal Affect Issue: 5.2

Funding: “This research was supported partially by Nationwide Aeronautics and House Administration (NASA) Grant Numbers 80NSSC22K1279 and NNX15AI21G. The authors acknowledge the Lombardi Complete Most cancers Shared Assets (MSR), that are partially supported by award quantity P30CA051008 (P.I. Louis Weiner) from the Nationwide Most cancers Institute.”

5

Tavakol DN, Nash TR, Kim Y, He S, Fleischer S, Graney PL, Brown JA, Liberman M, Tamargo M, Harken A, Ferrando AA, Amundson S, Garty G, Azizi E, Leong KW, Brenner DJ, Vunjak-Novakovic G.

Modeling and countering the results of cosmic radiation utilizing bioengineered human tissues.

Biomaterials. 2023 Oct;301:122267.

https://pubmed.ncbi.nlm.nih.gov/37633022

PI: G. Vunjak-Novakovic

Journal Affect Issue: 14

Funding: “We gratefully acknowledge the funding help of this work by the Nationwide Institutes of Well being (EB027062, HL076485, CA249799 to G.V.- N.; U19-AI067773, 1S10OD025190 to D.J.B.; K99 CA267168 to J.A.B.; 1F31CA275733 fellowship to D.N.T.), the Nationwide Science Basis (1644869 fellowship to D.N.T. and ERC16478 to G.V.-N.), the Empire State Improvement Company (AC710 to D.J.B), and the Translational Analysis Institute for House Well being (TRISH/NASA) company for his or her help (RAD0104 and NNX16AO69A to G.V.-N., D.J.B., Ok.L.).”

6

Caston RA, Fortini P, Chen Ok, Bauer J, Dogliotti E, Yin YW, Demple B.

Upkeep of flap endonucleases for long-patch base excision DNA restore in mouse muscle and neuronal cells differentiated in vitro.

Int J Mol Sci. 2023 Aug 12;24(16):12715.

https://pubmed.ncbi.nlm.nih.gov/37628896

Notice: This text is a part of Particular Challenge “Endogenous DNA Injury and Restore” (https://www.mdpi.com/journal/ijms/special_issues/416NG1LUQE). Further articles will probably be forthcoming and could also be discovered within the hyperlink to the Particular Challenge. This text could also be obtained on-line with out cost.

Journal Affect Issue: 5.6

Funding: “This analysis was funded by grants R21CA198752 and R21CA191856 from the U.S. Nationwide Most cancers Institute (PI: B. Demple), Nationwide Aeronautics and House Administration grants NNA14AB04A and 80NSSC19M0215 (P.I., Tim Glotch, Stony Brook College), and grant R01GM14925 from the U.S. Nationwide Institute of Normal Medical Sciences (P.I., Y.W.Y).”

7

Sander Ok, Abel AJ, Friedline S, Sharpless W, Skerker J, Deutschbauer A, Clark DS, Arkin AP.

Eliminating genes for a two-component system will increase PHB productiveness in Cupriavidus basilensis 4G11 beneath PHB suppressing, nonstress circumstances.

Biotechnol Bioeng. 2023 Aug 28. On-line forward of print.

https://pubmed.ncbi.nlm.nih.gov/37638652

Notice: This text could also be obtained on-line with out cost.

Journal Affect Issue: 3.8

Funding: “Nationwide Aeronautics and SpaceAdministration, Grant/Award Quantity: NNX17AJ31G.”

8

Raber J, Sharpton TJ.

Gastrointestinal dysfunction in neurological and neurodegenerative problems.

Semin Neurol. 2023 Aug 22. On-line forward of print.

https://doi.org/10.1055/s-0043-1771459

PI: J. Raber

Journal Affect Issue: 2.7

Funding: PI studies NASA Activity E book challenge “The Relation Between Cognitive Damage, Community Stability, and Epigenetic Change Following Publicity to House Radiation” funding.

_______________________________________________________

Different papers of curiosity:

1

Kim BS, Alcantara AVJ, Moon JH, Higashitani A, Higashitani N, Etheridge T, Szewczyk NJ, Deane CS, Gaffney CJ, Higashibata A, Hashizume T, Yoon KH, Lee JI.

Comparative evaluation of muscle atrophy throughout spaceflight, dietary deficiency and disuse within the nematode Caenorhabditis elegans.

Int J Mol Sci. 2023 Aug 10;24(16):12640.

https://pubmed.ncbi.nlm.nih.gov/37628820

Notice: ISS outcomes. This text is a part of Particular Challenge “Mobile and Molecular Signaling Meet the House Setting” (https://www.mdpi.com/journal/ijms/special_issues/Cellular_molecular_signaling_space). The Particular Challenge consists of articles from Present Consciousness lists #983 https://doi.org/10.3390/ijms23010075; #1,002 https://doi.org/10.3390/ijms23105593 and https://doi.org/10.3390/ijms23105489; #1,008 https://doi.org/10.3390/ijms23137465 and https://doi.org/10.3390/ijms23137133; #1,054 https://doi.org/10.3390/ijms24065955; and #1,058 https://doi.org/10.3390/ijms241311135. This text could also be obtained on-line with out cost.

2

Shimizu R, Hirano I, Hasegawa A, Suzuki M, Otsuki A, Taguchi Ok, Katsuoka F, Uruno A, Suzuki N, Yumoto A, Okada R, Shirakawa M, Shiba D, Takahashi S, Suzuki T, Yamamoto M.

Nrf2 alleviates spaceflight-induced immunosuppression and thrombotic microangiopathy in mice.

Commun Biol. 2023 Aug 25;6(1):875.

https://pubmed.ncbi.nlm.nih.gov/37626149

Notice: ISS outcomes. This text could also be obtained on-line with out cost.

3

Berkovich YA, Beliak AM, Bagretsova MR, Korshunov DV, Savostianova LI, Smolianina SO.

Methods to enhance the effectivity of synthetic soil used for root crops cultivation in an area greenhouse.

Aviakosm Ekolog Med. 2023;57(4):97-105. Russian.

https://elibrary.ru/merchandise.asp?id=54345682

4

Berseneva AP, Funtova II.

Prenosological diagnostics as a strategy of organism physiological situation evaluation and its place in area and terrestrial medication.

Aviakosm Ekolog Med. 2023;57(4):5-19. Russian.

https://www.elibrary.ru/merchandise.asp?id=54345671

Notice: From the summary: “A brand new idea of the doctrine of well being—

prenosological analysis—

originated in area medication. One of many founders of this doctrine was Roman Markovich Baevsky. This strategy was constructed not on the analysis of illnesses, however on the evaluation of the standard of well being with the allocation of 4 circumstances: passable adaptation; pressure of adaptation mechanisms; unsatisfactory adaptation; and failure to adapt.”

5

Izzo LG, El Nakhel C, Rouphael Y, Proietti S, Paglialunga G, Moscatello S, Battistelli A, Iovane M, Romano LE, De Pascale S, Aronne G.

Making use of productiveness and phytonutrient profile standards in modelling species choice of microgreens as area crops for astronaut consumption.

Entrance Plant Sci. 2023 Aug 11;14:1210566.

https://pubmed.ncbi.nlm.nih.gov/37636122

Notice: From the summary: “On this research we developed and utilized an algorithm to objectively examine quite a few genotypes of microgreens intending to pick out these with the most effective productiveness and phytonutrient profile for cultivation in House.” This text is a part of Analysis Subject “Micro-Scale Vegetable Manufacturing: Sprouts and Microgreens as Progressive Useful Meals” (https://www.frontiersin.org/research-topics/51760/micro-scale-vegetable-production-sprouts-and-microgreens-as-innovative-functional-foods#overview) and could also be obtained on-line with out cost.

6

Manzano A, Weging S, Bezdan D, Borg J, Cahill T, Carnero-Diaz E, Cope H, Deane CS, Etheridge T, Giacomello S, Hardiman G, Leys N, Madrigal P, Mastroleo F, Medina FJ, Mieczkowski J, Fernandez-Rojo MA, Siew Ok, Szewczyk NJ, Walsh SB, da Silveira WA, Herranz R.

Enhancing European capabilities for utility of multi-omics research in biology and biomedicine area analysis.

iScience. 2023 Sep 15;26(9):107289. Overview.

https://pubmed.ncbi.nlm.nih.gov/37636054

Notice: This text could also be obtained on-line with out cost.

7

Berardini M, Gesualdi L, Morabito C, Ferranti F, Reale A, Zampieri M, Karpach Ok, Tinari A, Bertuccini L, Guarnieri S, Catizone A, Mariggiò MA, Ricci G.

Simulated microgravity publicity induces antioxidant barrier deregulation and mitochondria enlargement in TCam-2 cell spheroids.

Cells. 2023 Aug 19;12(16):2106.

https://pubmed.ncbi.nlm.nih.gov/37626916

Notice: A random positioning machine was used on this research. This text is a part of Particular Challenge “New Insights into Microgravity and House Biology” (https://www.mdpi.com/journal/cells/special_issues/R75D12X7FZ). The Particular Challenge additionally consists of articles from earlier Present Consciousness Lists #1,028 https://doi.org/10.3390/cells11233871; #1,032 https://doi.org/10.3390/cells12020246; #1,041 https://doi.org/10.3390/cells12050691 and https://doi.org/10.3390/cells12050734; and #1,061 https://doi.org/10.3390/cells12141907. This text could also be obtained on-line with out cost.

8

De Micco V, Amitrano C, Mastroleo F, Aronne G, Battistelli A, Carnero-Diaz E, De Pascale S, Detrell G, Dussap CG, Ganigué R, Jakobsen ØM, Poulet L, Van Houdt R, Verseux C, Vlaeminck SE, Willaert R, Leys N.

Plant and microbial science and know-how as cornerstones to bioregenerative life help techniques in area.

npj Microgravity. 2023 Aug 24;9(1):69. Overview.

https://pubmed.ncbi.nlm.nih.gov/37620398

Notice: This text could also be obtained on-line with out cost.

9

Gallardo-Dodd CJ, Oertlin C, Document J, Galvani RG, Sommerauer C, Kuznetsov NV, Doukoumopoulos E, Ali L, Oliveira MMS, Seitz C, Percipalle M, Nikić T, Sadova AA, Shulgina SM, Shmarov VA, Kutko OV, Vlasova DD, Orlova KD, Rykova MP, Andersson J, Percipalle P, Kutter C, Ponomarev SA, Westerberg LS.

Publicity of volunteers to microgravity by dry immersion mattress over 21 days ends in gene expression adjustments and adaptation of T cells.

Sci Adv. 2023 Aug 25;9(34):eadg1610.

https://pubmed.ncbi.nlm.nih.gov/37624890

Notice: This text could also be obtained on-line with out cost.

10

Golubkova MA, Ogneva IV.

The content material of cytoskeletal proteins, mrna of related genes, and post-translational histone modifications in Drosophila melanogaster ovaries within the situation of simulated microgravity.

Aviakosm Ekolog Med. 2023;57(4):71-7. Russian.

https://www.elibrary.ru/merchandise.asp?id=54345679

11

Moroz GA, Kriventsov MA, Kutia SA.

The impact of systematic gravitational overloads on the structural group of the adrenals and thymus in an experiment.

Aviakosm Ekolog Med. 2023;57(4):78-86. Russian.

https://www.elibrary.ru/merchandise.asp?id=54345680

12

Supolkina NS, Shved DM, Yusupova AK, Gushchin VI, Ryumin OO.

The principle phenomena in cosmonauts’ communication throughout the crew mission management middle communication system and the necessity for modifications.

Aviakosm Ekolog Med. 2023;57(4):20-5. Russian.

https://www.elibrary.ru/merchandise.asp?id=54345672

13

Ramey-Ward AN, Dong Y, Yang J, Ogasawara H, Bremer-Sai EC, Brazhkina O, Franck C, Davis M, Salaita Ok.

Optomechanically actuated hydrogel platform for cell stimulation with spatial and temporal decision.

ACS Biomater Sci Eng. 2023 Aug 21. On-line forward of print.

https://pubmed.ncbi.nlm.nih.gov/37604774

14

Naumova AA, Oleynik EA, Grigorieva YS, Nikolaeva SD, Chernigovskaya EV, Glazova MV.

Seeking stress: Evaluation of stress-related markers in mice after hindlimb unloading and social isolation.

Neurol Res. 2023 Aug 29;1-12.

https://pubmed.ncbi.nlm.nih.gov/37642364

Notice: Hindlimb unloading research.

15

Puchkova AA, Shpakov AV, Baranov VM, Katuntsev VP, Stavrovskaya DM, Primachenko GK, Gorbachev VP, Tomilovskaya ES, Orlov OI.

Normal outcomes of the 21-day head-down bedrest research with out using prophylaxis.

Aviakosm Ekolog Med. 2023;57(4):31-41. Russian.

https://www.elibrary.ru/merchandise.asp?id=54345674

Notice: Head-down bedrest research.

16

Versteeg N, Clijsen R, Hohenauer E.

Results of 3-week repeated chilly water immersion on leukocyte counts and cardiovascular components: An exploratory research.

Entrance Physiol. 2023 Aug 29;14:1197585.

https://doi.org/10.3389/fphys.2023.1197585

Notice: This text is a part of Particular Challenge “Chilly, Warmth and Hypoxia as a Medical Device: The Use in a Wholesome and Diseased Inhabitants” (https://www.frontiersin.org/research-topics/48889/cold-heat-and-hypoxia-as-a-medical-tool-the-use-in-a-healthy-and-diseased-population#overview). The Particular Challenge additionally consists of articles from earlier Present Consciousness Lists #1,050 https://doi.org/10.3389/fphys.2023.1173171 and #1,057 https://doi.org/10.3389/fphys.2023.1213733. This text could also be obtained on-line with out cost.

17

Sobel AL, Orford R, Klingenberger Ok.

The way in which forward: Adaptive medical requirements to optimize business area traveler well being, security, and efficiency.

Entrance House Technol. 2023 Aug 31;4:1155432.

https://doi.org/10.3389/frspt.2023.1155432

Notice: This text is a part of Analysis Subject “Quick Transit, Crew Well being, and Efficiency on Prolonged Length House Missions” (https://www.frontiersin.org/research-topics/46048/fast-transit-crew-health-and-performance-on-extended-duration-space-missions#overview). The Analysis Subject additionally consists of articles from earlier Present Consciousness Lists #1,053 https://doi.org/10.3389/fpubh.2023.1161124 and #1,058 https://doi.org/10.3389/fpubh.2023.1181911. This text could also be obtained on-line with out cost.

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