NASA Spaceline Current Awareness List #1,063 25 August 2023 (Space Life Science Research Results)

NASA Spaceline Current Awareness List #1,063 25 August 2023 (Space Life Science Research Results)

Astronaut Peggy Whitson At Work on the ISS


SPACELINE Present Consciousness Lists are distributed by way of listserv and can be found on the NASA Process Guide web site at Please ship any correspondence to Shawna Byrd, SPACELINE Present Consciousness Senior Editor, [email protected].

Name for articles to quote within the weekly lists: Authors at NASA Facilities and NASA PIs—do you have got an article that has lately printed or will publish within the upcoming weeks inside a peer-reviewed journal and is within the scope of area life sciences? If that’s the case, ship it our manner! Ship your article to the e-mail handle talked about above. Articles acquired by Wednesday will seem inside that week’s listing—articles acquired after Wednesday will seem the next week.

Papers deriving from NASA assist:


Nakashima J, Pattathil S, Avci U, Chin S, Alan Sparks J, Hahn MG, Gilroy S, Blancaflor EB.

Glycome profiling and immunohistochemistry uncover adjustments in cell partitions of Arabidopsis thaliana roots throughout spaceflight.

npj Microgravity. 2023 Aug 22;9:68.

PIs: S. Gilroy, E.B. Blancaflor

Observe: ISS outcomes. This text could also be obtained on-line with out cost.

Journal Affect Issue: 5.1

Funding: “This work was supported by NASA grants NNX12AM94G and 80NSSC19K0129 (to E.B.B.), 80NSSC18K1462 and 80NSSC22K0024 (to S.G. and S.C.). Plant cell wall glycan-directed antibodies used right here have been generated with funsding from the Nationwide Science Basis Plant Genome Program (DBI-0421683, to M.G.H.). Glycome profiling of samples described right here was supported by a grant to MGH from the NSF Plant Genome Program (IOS-0923992). We thank Allison Mjoen, Howard Levine, Bryan Onate, Jose Camacho, Trent Smith, Gioia Massa, Colleen Huber, John Carver, Shawn Stephens, Gerald Newsham, David Reed, and Stacy Engel at NASA-Kennedy House Middle for technical assist throughout floor and spaceflight operations.”


Shibata S, Wakeham DJ, Thomas JD, Abdullah SM, Platts S, Bungo MW, Levine BD.

Cardiac results of long-duration spaceflight.

J Am Coll Cardiol. 2023 Aug 22;82(8):674-84.

PI: B.D. Levine

Observe: ISS outcomes.

Journal Affect Issue: 24

Funding: “This examine was funded by NASA grant NNJ04HH01A to Drs. Levine and Bungo.”


Stepaniak PC, Blue RS, Gilmore S, Beven GE, Chough NG, Tsung A, McMonigal KA, Mazuchowski EL, 2nd

, Bytheway JA, Lindgren KN, Barratt MR.

Operational concerns for crew fatality on the Worldwide House Station.

Aerosp Med Hum Carry out. 2023 Sep 1;94(9):705-14.

Observe: From the summary: “Right here, we element the operational concerns for a crew fatality ought to it happen throughout spaceflight onboard the ISS, together with forensic and timeline constraints, behavioral well being elements, and concerns for last disposition of decedent stays.”

Journal Affect Issue: 0.889

Funding: “This challenge was funded by the NASA/JSC HH&P Directorate and the energetic knowledge assortment phases have been undertaken from November 2017 via December 2019. Efforts have been coordinated with a number of stakeholders, together with NASA JSC (Houston, TX), the Armed Forces Medical Examiner System (AFMES) and Air Power Mortuary Affairs Operation (Dover Air Power Base, DE); the Sam Houston State College (SHSU) Division of Chemistry and their Utilized Anatomical Analysis Middle/Southeast Texas Utilized Forensic Science (STAFS) Facility (Huntsville, TX); the College of Texas Medical Department (UTMB) College of Preventive Medication and Inhabitants Well being (Galveston, TX); Kellogg-Brown-Root (KBR) (Houston, TX); Isovac Merchandise LLC (Romeoville, IL); and the NASA Multilateral Medical Operations Panel (MMOP) worldwide companions from the Russian Federation House Company (RFSA), European House Company (ESA), Japan Aerospace Exploration Company (JAXA), and the Canadian House Company (CSA).”


Hughes AM, Vandenbrink JP, Kiss JZ.

Efficacy of the random positioning machine as a terrestrial analogue to microgravity in research of seedling phototropism.

Microgravity Sci Technol. 2023 Aug 14;35:43.

PI: J.Z. Kiss

Observe: From the summary: “On this examine, we evaluate the outcomes from experiments carried out on the Worldwide House Station with these carried out utilizing the random positioning machine (within the 3D clinostat mode) on the bottom.”

Journal Affect Issue: 1.8

Funding: “Funding for this analysis was offered by a grant from NASA (Nationwide Aeronautics and House Administration) to John Z. Kiss (grant quantity 80NSSC17K0546).”


Allred AR, Clark TK.

A computational mannequin of movement illness dynamics throughout passive self-motion in the dead of night.

Exp Mind Res. 2023 Aug 17.

Observe: From the summary: “Predicting the time course of movement illness signs permits the analysis of provocative stimuli and the event of countermeasures for decreasing symptom severity. In pursuit of this aim, we current an observer-driven mannequin of movement illness for passive motions in the dead of night. Constructed in two levels, this mannequin predicts movement illness signs by bridging sensory battle (i.e., variations between precise and anticipated sensory alerts) arising from the observer mannequin of spatial orientation notion (stage 1) to Oman’s mannequin of movement illness symptom dynamics (stage 2; offered in 1982 and 1990) via a proposed ‘Normalized innovation squared statistic.’”

Journal Affect Issue: 2.0

Funding: “This work was supported by a NASA House Know-how Graduate Analysis Alternatives Award. House Know-how Mission Directorate, 80NSSC20K1202, Aaron Allred.”


Hoppock GA, Buettmann EG, Denisco JA, Goldscheitter GM, Condyles SN, Juhl OJ 4th

, Friedman MA, Zhang Y, Donahue HJ.

Connexin 43 and cell tradition substrate differentially regulate OCY454 osteocytic differentiation and signaling to major bone cells.

Am J Physiol Cell Physiol. 2023 Aug 21. On-line forward of print.

PIs: E.G. Buettmann, M.A. Friedman

Observe: From the summary: “Connexin 43 (Cx43), the predominate hole junction protein in bone, is important for intercellular communication and skeletal homeostasis. Earlier work suggests osteocyte-specific deletion of Cx43 results in elevated bone formation and resorption; nonetheless, the cell-autonomous function of osteocytic Cx43 in selling elevated bone reworking is unknown. Current research utilizing 3D tradition substrates in OCY454 cells recommend 3D cultures could provide elevated bone reworking issue expression and secretion, comparable to sclerostin and RANKL. On this examine, we in contrast culturing OCY454 osteocytes on 3D Alvetex scaffolds to conventional 2D tissue tradition, each with (WT) and with out Cx43 (Cx43 KO).”

Journal Affect Issue: 5.5

Funding: “80NSSC18KK1473/Nationwide Aeronautics and House Administration (NASA); R01AR068132/HHS | Nationwide Institutes of Well being (NIH); NNX16AO69A/Nationwide Aeronautics and House Administration (NASA).”


Thompson EA, Fowlkes NW, Jacobsen MC, Layman RR, Cressman ENK.

Quantitative dual-energy CT picture steerage for thermochemical ablation: In vivo leads to the rabbit VX2 mannequin.

J Vasc Interv Radiol. 2023 Might;34(5):782-9.

Journal Affect Issue: 2.9

Funding: “E.A.T. experiences a Society of Interventional Radiology (SIR) Basis Allied Scientist Coaching Grant, a Most cancers Prevention and Analysis Institute of Texas Graduate Scholar Award (RP210028), and a grant (R01CA201127) from the Nationwide Institutes of Well being. R.R.L. experiences receiving the next grants: NIH S10 1S10OD028621-01A1, Most cancers Prevention and Analysis Institute of Texas RP220366, USDA Small Enterprise Innovation Analysis NIFA Part II, MDACC Institutional Analysis Grant, NIH 5R01HL141831-04, NASA 80NSSC18K1639, T32 FP 13417, and SIR FP10908; talking honoraria from American School of Radiology Regional Chapter; advisory board participation in GE Healthcare; management function as American Affiliation of Physicists in Medication Process Group Co-Chair; and receipt of analysis supplies from Siemens Healthineers and MARS Bioimaging Ltd. E.N.Ok.C. experiences management roles within the SIR Annual Assembly Committee and World Embolization and Applied sciences Assembly Analysis Committee.”


Naruse M, Vincenty CS, Konopka AR, Trappe SW, Harber MP, Trappe TA.

Cycle train coaching and muscle mass: A preliminary investigation of 17 decrease limb muscle mass in older males.

Physiol Rep. 2023 Aug 22;11(16):e15781.

Observe: This text could also be obtained on-line with out cost.

Journal Affect Issue: 0.78

Funding: “This examine was supported by NIH Grant AG032127 and NASA Grant NNJ06HF59G.”


Wong CP, Iwaniec UT, Turner RT.

Brown adipose tissue however not tibia displays a dramatic response to acute discount in environmental temperature in rising male mice.

Bone Rep. 2023 Dec 19;101706.

PI: R.T. Turner

Journal Affect Issue: 2.5

Funding: “This work was supported by the Nationwide Aeronautics and House Administration (80NSSC19K0430).”


Soroczynski J, Risca VI.

Technological advances in probing 4D genome group.

Curr Opin Cell Biol. 2023 Oct 23;84:102211.

PI: V.I. Risca

Journal Affect Issue: 7.5

Funding: “This work was supported by grants from the Rita Allen Basis (Scholar Grant), the Irma T. Hirschl/Monique Weill-Caulier Belief (Profession Scientist Award), the Starr Most cancers Consortium (grant quantity I16-0058), the Nationwide Aeronautics and House Administration (grant quantity 80NSSC21K0565) and the Nationwide Institutes of Well being (grant quantity DP2GM150021). …”


Different papers of curiosity:


De Micco V, Aronne G, Caplin N, Carnero-Diaz E, Herranz R, Horemans N, Legué V, Medina FJ, Pereda-Loth V, Schiefloe M, De Francesco S, Izzo LG, Le Disquet I, Kittang Jost AI.

Views for plant biology in area and analogue environments.

npj Microgravity. 2023 Aug 21;9(1):67. Overview.

Observe: This text could also be obtained on-line with out cost.


Cucinotta FA.

Non-targeted results and area radiation dangers for astronauts on a number of Worldwide House Station and Lunar missions.

Life Sci House Res. 2023 Aug 23. On-line forward of print.

Observe: Opinion/Place article.


Tommaso CL.

Lengthy-duration spaceflight and cardiac morphology: To boldly go the place no man has gone earlier than.

J Am Coll Cardiol. 2023 Aug 22;82(8):685-6.

Observe: This text is an editorial.


Goto M, Shibata Y, Ishiyama S, Matsumaru Y, Ishikawa E.

Mind microstructure and mind perform adjustments in area headache by head-down-tilted bedrest.

Aerosp Med Hum Carry out. 2023 Sep;94(9):678-85.

Observe: Head-down tilt bedrest.


Santhoshkumar P, Negi A, Moses JA.

3D printing for area meals functions: Developments, challenges, and prospects.

Life Sci House Res. 2023 Aug 22. On-line forward of print.

Observe: From the summary: “House meals intently affiliate with the efficiency and psychological well being of astronauts. Through the years, a spread of producing applied sciences have been explored and developments in meals 3D printing can present solutions to sure present challenges and revolutionize the way in which meals are ready for area exploration missions. Other than the vitamin and satiety perspective, product shelf-life, selection, personalization, and the necessity for personalized diets are important concerns. In such long-duration human-crewed area missions, below microgravity circumstances and publicity to area, psychological elements closely have an effect on meals consumption patterns. Subsequently, there was a surge in analysis funding for creating merchandise and strategies that provide protected, nutritionally balanced, and pleasant meals choices. 3D meals printing could possibly be a inventive resolution for such necessities.”


Dwi Setiawan G, Thiravetyan P, Treesubsuntorn C.

Gaseous toluene phytoremediation by Vigna radiata seedlings below simulated microgravity: Impact of hypocotyl, auxin, and gibberellic acid.

Acta Astronaut. 2023 Oct;211:88-96.

Observe: A random positioning machine was used on this examine.


Shi Q, Gui J, Solar L, Tune Y, Na J, Zhang J, Fan Y, Zheng L.

Frizzled-9 triggers actin polymerization and prompts mechano-transducer YAP to rescue simulated microgravity-induced osteoblast dysfunction.

Faseb j. 2023 Sep;37(9):e23147.

Observe: Hindlimb unloading examine.


Varis N, Leinonen A, Perälä J, Leino TK, Husa L, Sovelius R.

Delayed drowsiness after normobaric hypoxia coaching in an F/A-18 hornet simulator.

Aerosp Med Hum Carry out. 2023 Sep;94(9):715-8.

Observe: From the summary: “This case report demonstrates the hazard of deep hypoxia. Hypoxia coaching directions ought to embody restrictions associated to driving a automobile instantly after hypoxia coaching. As well as, hypoxia could decrease the mind threshold for sopite syndrome.”


Connolly DM, D’Oyly TJ, Harridge SDR, Smith TG, Lee VM.

Decompression illness threat in parachutist dispatchers uncovered repeatedly to excessive altitude.

Aerosp Med Hum Carry out. 2023 Sep;94(9):666-77.


Vallée N, Dugrenot E, Desruelle A-V, Richard S, Coupé S, Ramdani C, Guieu R, Risso J-J, Gaillard S, Guerrero F.

Highlighting of the interactions of MYD88 and NFKB1 SNPs in rats immune to decompression illness: Towards an autoimmune response.

Entrance Physiol. 2023 Aug 17;14:1253856.

Observe: This text could also be obtained on-line with out cost.


Brighton EM, Klaus DM.

Categorization of choose cockpit efficiency analysis methods.

Aerosp Med Hum Carry out. 2023 Sep;94(9):696-704.

Observe: From the summary: “The fashionable plane cockpit has advanced into a posh system of methods. Quite a few efficiency analysis metrics and methods exist that may measure the effectiveness of cockpit parts by way of how they affect the human operator’s capability to carry out duties related to mission success. As no prior evaluation of those metrics has been discovered within the literature, this effort makes an attempt to take action, albeit with out making use of the metrics to a novel cockpit analysis.”


Chu V, Newman DG.

Train impact on psychological well being in isolating or quarantining adults.

Aerosp Med Hum Carry out. 2023 Sep;94(9):686-95.


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