NASA Spaceline Current Awareness List #1,072 – 27 October 2023 (Space Life Science Research Results)

NASA Spaceline Current Awareness List #1,072 – 27 October 2023 (Space Life Science Research Results)

SPACELINE Present Consciousness Lists are distributed by way of listserv and can be found on the NASA Activity Ebook web site at Please ship any correspondence to Shawna Byrd, SPACELINE Present Consciousness Senior Editor,

Name for articles to quote within the weekly lists: Authors at NASA Facilities and NASA PIs—do you might have an article that has not too long ago printed or will publish within the upcoming weeks inside a peer-reviewed journal and is within the scope of area life sciences? In that case, ship it our means! Ship your article to the e-mail tackle talked about above. Articles obtained by Wednesday will seem inside that week’s checklist—articles obtained after Wednesday will seem the next week.

Papers deriving from NASA assist:


Soni P, Edwards H, Anupom T, Rahman M, Lesanpezeshki L, Blawzdziewicz J, Cope H, Gharahdaghi N, Scott D, Toh LS, Williams PM, Etheridge T, Szewczyk N, Willis CRG, Vanapalli SA.

Spaceflight induces energy decline in Caenorhabditis elegans.

Cells. 2023 Oct 17;12(20):2470.

PI: S.A. Vanapalli

Word: ISS outcomes. This text is a part of Particular Challenge “New Insights into Microgravity and House Biology” ( The Particular Challenge additionally consists of articles from earlier Present Consciousness Lists #1,028; #1,032; #1,041 and; #1,061; and #1,064 This text could also be obtained on-line with out cost.

Journal Impression Issue: 6.0

Funding: “This work was supported by funding from NASA (Grant # NNX15AL16GG and NNJ15GK01C) and the UK BBSRC (Grant # BB/N015894/1). H.C. is supported by the Horizon Middle for Doctoral Coaching on the College of Nottingham (UKRI grant # EP/S023305/1). NS was supported by grants from NASA (NSSC22K0250; NSSC22K0278) and acknowledges the assist of the Osteopathic Heritage Basis via funding for the Osetopathic Heritage Basis Ralph S. Licklider, D.O., Analysis Endowment within the Heritage School of Osteopathic Drugs.”


El-Khoury BB, Ray KL, Altchuler SI, Reichard JF, Dukes CH.

Selective serotonin reuptake inhibitors and different remedy modalities for deep area missions.

Aerosp Med Hum Carry out. 2023 Nov;94(11):843-51. Evaluation.

Word: From the summary: “As humankind ventures additional into the depths of area, planning is already underway for long-duration exploration missions that may take a look at the bounds of human efficiency. Deep area journey will embody added danger associated to stressors from the remoted, confined, and excessive setting that lies exterior the boundaries of low Earth orbit. At the moment, selective serotonin reuptake inhibitors (SSRIs) are thought of the usual of care for a lot of psychological well being diagnoses, together with anxiousness and melancholy; nonetheless, SSRIs are additionally related to a number of undesired unintended effects. The utility of nonpharmacological therapies for the administration of behavioral well being situations has not but been absolutely explored.”

Journal Impression Issue: 0.889

Funding: J.F. Reichard and C.H. Dukes are affiliated with NASA Johnson House Middle.


Manon J, Saint-Guillain M, Pletser V, Buckland DM, Vico L, Dobney W, Baatout S, Wain C, Jacobs J, Comein A, Drouet S, Meert J, Casla IS, Chamart C, Vanderdonckt J, Cartiaux O, Cornu O.

Adequacy of in-mission coaching to deal with tibial shaft fractures in Mars analogue testing.

Sci Rep. 2023 Oct 23;13:18072.

Word: This text could also be obtained on-line with out cost.

Journal Impression Issue: 4.6

Funding: D.M. Buckland is affiliated with NASA Johnson House Middle.


Waisberg E, Ong J, Zaman N, Kamran SA, Sarker P, Tavakkoli A, Lee AG.

Head-mounted show cataract surgical procedure: A brand new frontier with eye monitoring and foveated rendering expertise.

Eye (Lond). 2023 Oct 19.

PI: A. Tavakkoli

Word: This text is a correspondence.

Journal Impression Issue: 3.9

Funding: “NASA Grant [80NSSC20K183]: A non-intrusive ocular monitoring framework to mannequin ocular construction and purposeful modifications on account of long-term spaceflight.”


Zaman N, Ong J, Waisberg E, Masalkhi M, Lee AG, Tavakkoli A, Zuckerbrod S.

Superior visualization engineering for imaginative and prescient issues: A clinically centered information to present expertise and future purposes.

Ann Biomed Eng. 2023 Oct 20. Evaluation.

PI: A. Tavakkoli

Journal Impression Issue: 3.8

Funding: “NASA Grant [80NSSC20K183]: A Non-intrusive Ocular Monitoring Framework to Mannequin Ocular Construction and Useful Modifications on account of Lengthy-term Spaceflight.”


Walsh RFL, Klugman J, Moriarity DP, Titone MK, Ng TH, Goel N, Alloy LB.

Reward sensitivity and social rhythms throughout goal-striving: An ecological momentary evaluation investigation of bipolar spectrum issues.

J Have an effect on Disord. 2023 Oct 16;344:510-8.

PI: N. Goel

Journal Impression Issue: 6.6

Funding: “This research was supported partially by the Nationwide Science Basis’s Graduate Analysis Fellowship to Rachel Walsh and by Nationwide Institute of Psychological Well being R01 grants MH077908, MH102310, and MH126911 to Lauren B. Alloy. Namni Goel was supported partially by the Nationwide Aeronautics and House Administration (NASA) grants NNX14AN49G and 80NSSC20K0243 and Nationwide Institutes of Well being grant R01DK117488.”


Different papers of curiosity:


Masís Solano M, Bélanger Nzakimuena C, Dumas R, Lesk MR, Costantino S.

Ocular rigidity and choroidal thickness modifications in response to microgravity: A case research.

Am J Ophthalmol Case Rep. 2023 Dec;32:101940.

Word: ISS outcomes.


Kovalski E, Salazar L, Levin D, Kamine TH.

A 3D-printed transportable sterilizer for use throughout surgical procedures in spaceflight.

Aerosp Med Hum Carry out. 2023 Nov;94(11):857-60.

Word: From the summary: “Throughout spaceflight, you will need to think about the mechanisms by which surgical procedures and medical procedures might be safely and effectively carried out. Devices used to hold out these processes must be sterilized. Thus, now we have designed and examined a three-dimensional-printed (3D-printed) transportable sterilizer that implements far ultraviolet-C (Far UV-C) mild radiation to disinfect micro organism and microorganisms from surgical devices.”


Narici L, Berger T.

Radiation in human area exploration: Detectors and measurements, at present and tomorrow.

Life Sci House Res. 2023 Oct 22. On-line forward of print.


Majumder N, Ghosh S.

3D biofabrication and area: A “far-fetched dream” or a “forthcoming actuality?”

Biotechnol Adv. 2023 Dec;69:108273. Evaluation.


Cialdai F, Brown AM, Baumann CW, Angeloni D, Baatout S, Benchoua A, Bereiter-Hahn J, Bottai D, Buchheim JI, Calvaruso M, Carnero-Diaz E, Castiglioni S, Cavalieri D, Ceccarelli G, Choukér A, Ciofani G, Coppola G, Cusella G, Degl’Innocenti A, Desaphy JF, Frippiat JP, Gelinsky M, Genchi G, Grano M, Grimm D, Guignandon A, Hahn C, Hatton J, Herranz R, Hellweg CE, Iorio CS, Karapantsios T, van Loon J, Lulli M, Maier J, Malda J, Mamaca E, Morbidelli L, van Ombergen A, Osterman A, Ovsianikov A, Pampaloni F, Pavezlorie E, Pereda-Campos V, Przybyla C, Puhl C, Rettberg P, Risaliti C, Rizzo AM, Robson-Brown Okay, Rossi L, Russo G, Salvetti A, Santucci D, Sperl M, Strollo F, Tabury Okay, Tavella S, Thielemann C, Willaert R, Szewczyk NJ, Monici M.

How do gravity alterations have an effect on animal and human methods at a mobile/tissue degree?

npj Microgravity. 2023 Oct 21;9:84.

Word: This text could also be obtained on-line with out cost.


Liang R, Wang L, Yang Q, Xu Q, Solar S, Zhou H, Zhao M, Gao J, Zheng C, Yang J, Ming D.

Time-course adaptive modifications in hippocampal transcriptome and synaptic operate induced by simulated microgravity related to cognition.

Entrance Cell Neurosci. 2023 Oct 5;17:1275771.

Word: Hindlimb unloading research. This text is a part of Analysis Subject “House and Neural Cell: The Impression of House Surroundings on Neurological Operate and Their Molecular Mechanistic Insights” ( and could also be obtained on-line with out cost.


Boyd DD, Scharf MT.

Poor aeronautical decision-making contributions to deadly basic aviation accidents.

Aerosp Med Hum Carry out. 2023 Nov;94(11):807-14.


Wei W, Bai H, Zhang T, Cai S, Zhou Y, Liu M, Zhang Y, Chen Y, Hua J, He J, Ding N, Miao G, Wang J.

Regulation of circulating miR-342-3p alleviates the radiation-induced immune system harm.

Radiat Res. 2023 Oct 24. On-line forward of print.

Word: From the summary: “Ionizing radiation in area, radiation gadgets or nuclear disasters are main threats to human well being and public safety. Increasing countermeasures for coping with unintended or occupational radiation publicity is essential for the safety of radiation accidents. Circulating microRNAs (miRNAs) have emerged as promising radiation biomarkers in recent times. Nonetheless, the origin, distribution and features of radiosensitive circulating miRNAs stay unclear, which obstructs their scientific purposes sooner or later. On this research, we discovered that mmu-miR-342-3p (miR-342) in mouse serum presents a secure and vital lower after X-ray total-body irradiation (TBI). Specializing in this miRNA, we investigated the influences of circulating miR-342 on the radiation-induced harm.”


Li Y, Solar W, Li J, Du R, Xing W, Yuan X, Zhong G, Zhao D, Liu Z, Jin X, Pan J, Li Y, Li Q, Kan G, Han X, Ling S, Solar X, Li Y.

HuR-mediated nucleocytoplasmic translocation of HOTAIR relieves its inhibition of osteogenic differentiation and promotes bone formation.

Bone Res. 2023 Oct 23;11:53.

Word: This text could also be obtained on-line with out cost.


Brahmanti RS, Sampurna B, Ibrahim N, Adi NP, Siagian M, Werdhani RA.

Weight problems and its relation to extreme daytime sleepiness in civilian pilots.

Aerosp Med Hum Carry out. 2023 Nov;94(11):815-20.


Mecusker ED.

Memorial spaceflights and extraterrestrial burial.

Most cancers Deal with Res. 2023 Oct 19;187:341-5. On-line forward of print.

Word: From the summary: “The human need to discover our world has led to dramatic shifts in science, expertise, and tradition. As our data expands so too has our capacity to extra definitively attain locations as soon as thought inhospitable or past our grasp. Within the early ages of human historical past, the oceans represented an enormous unknown, stuffed with rage and hazard suggesting the area of a tempestuous god or gods. As crusing and navigation developed, our eyes turned to the celebs and heavens as the brand new, last frontier. The vacancy past Earth’s environment has solely not too long ago develop into a vacation spot to sate our pure curiosity and, at current, life in outer area stays a dream of science fiction or the fortunate few who take part within the scientific research of our universe. For individuals who really feel cheated in being born too late to discover Earth, but in addition born too early to discover the cosmos, there’s a burgeoning area memorials trade which will give some comfort.”


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