UC Davis, Mars Find New Method for Low-Calorie Sweetener Production

Scientists on the College of California, Davis, in partnership with the Mars Superior Analysis Institute, have introduced a major breakthrough within the manufacturing of low-calorie sugar substitutes, similar to allulose. This discovery might assist tackle one of many major obstacles to the widespread adoption of those options: manufacturing prices.

Allulose, also referred to as D-psicose, is a naturally occurring uncommon sugar that gives a viable different to sucrose (desk sugar). It has an identical style, texture and performance, making it a pretty choice for these in search of to scale back their sugar consumption. By activating a pure course of in a microorganism, researchers have developed a technique for high-yield and high-purity manufacturing by means of exact fermentation. This advance has the potential to enormously improve the affordability and accessibility of those merchandise.

Allulose offers almost 70% taste and candy style as sucrose, but it’s minimally metabolized because it passes by means of the physique. By incorporating it into meals merchandise, people can scale back their calorie consumption from sugar whereas nonetheless satisfying their need for candy flavors. Moreover, allulose has an imperceptible impact on blood glucose and insulin ranges.

“Allulose is a superb different to sugar, however we’ve got not had an economical strategy to manufacture it,” mentioned Shota Atsumi, professor of chemistry at UC Davis and corresponding creator on the paper printed Oct. 14 in npj Science of Meals. “Our new methodology is environment friendly, economically possible and may very well be scaled up for business manufacturing.”

The brand new strategy has a greater than 99% theoretical yield with excessive purity, and subsequently solely requires minimal processing to isolate the specified product. Present strategies of allulose manufacturing are usually restricted to a lot decrease ranges of yield and purity, requiring costly separation strategies to isolate allulose from the glucose and fructose beginning materials.

Redirecting present course of

Atsumi, Ph.D. candidate Jayce Taylor, Professor Justin Siegel and plenty of co-workers within the Division of Chemistry and from Mars Superior Analysis Institute appeared for a extra environment friendly strategy to manufacture allulose. They discovered an industrial microorganism that has the enzymes to make allulose – it simply is not utilizing them in that means. They had been in a position to edit the organism’s metabolism to get the cells to transform glucose into allulose. The cells eat all of the glucose they’re fed and convert it to allulose with a noteworthy focus, a yield of over 60%, and purity of over 95%, outperforming the prevailing manufacturing strategies.

“As soon as flux was redirected, it seems the cells have all the things they should do it; they simply wanted to be turned on and undesired pathways turned off,” Atsumi mentioned.

UC Davis has filed patent purposes on the method and modified organisms. Researchers are working with a business associate to debate scaling up the method.

Extra co-authors are Dileep Sai Kumar Palur, Angela Zhang, Jake Gonzales, Augustine Arredondo, Timothy Coulther, Amiruddin Bin Johan Lechner, Elys Rodriguez and Oliver Fiehn at UC Davis; and John Didzbalis, Mars Integrated, McLean, Virginia.

The work and analysis by UC Davis had been supported and funded by Mars, Integrated.

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